Clonality and Evolutionary History of Rhabdomyosarcoma

Clonality and Evolutionary History of Rhabdomyosarcoma

To infer the subclonality of rhabdomyosarcoma (RMS) and predict the temporal order of genetic events for the tumorigenic process, and to identify novel drivers, we applied a systematic method that takes into account germline and somatic alterations in 44 tumor-normal RMS pairs using deep whole-genome sequencing. Intriguingly, we find that loss of heterozygosity of 11p15.5 and mutations in RAS p...

Biomineralization and Evolutionary History

The Dutch ethologist Niko Tinbergen famously distinguished between proximal and ultimate explanations in biology. Proximally, biologists seek a mechanistic understanding of how organisms function; most of this volume addresses the molecular and physiological bases of biomineralization. But while much of biology might be viewed as a particularly interesting form of chemistry, it is more than tha...

Evolutionary History of Behavior

History of Evolutionary Theory

The term "evolution" is linked to the idea of development in the sciences of life, and only subsequently did it acquire the present meaning of diversification and origin of new species. The dominant image of the scala naturae, strictly related to the creationist, static and essentialistic positions, was substituted by the image of the tree that characterizes the transformist theories, and that ...

Evolutionary history and species interactions.

W e celebrate this year the sesquicentennial anniversary of the publication of On the Origin of Species (1), one of the most important books ever written. The two great themes of The Origin are descent, with modification, of diverse species from common ancestors, and natural selection, which Darwin proposed as the chief agent of modification. He remarked, in Chapter VI, that ‘‘it is generally a...